Sermorelin is a synthetic form of growth hormone–releasing hormone (GHRH), designed to gently stimulate your own pituitary gland to release more natural growth hormone, rather than replacing it with synthetic GH. It works high up in the hormone cascade, sending a signal from the brain that encourages pulses of growth hormone, especially at night during deep sleep, which is when the body does much of its repair, regeneration and tissue maintenance. By supporting this system, Sermorelin is often used in programs that target better recovery, improved body composition, deeper sleep and long-term healthy ageing.

Typically benefits will happen over weeks and months, not overnight. 

It’s particularly popular in people who feel “a bit flat” hormonally but who don’t qualify for, or don’t want, full growth hormone replacement, and prefer working with their body’s own physiology instead. 

Because Sermorelin stimulates the body’s own GH rhythm, it allows the natural feedback system to remain in place, which is one reason it is often considered a more physiologic option than exogenous GH in wellness and optimisation settings.

Sermorelin  is not an FDA‑approved medicine and is not intended to diagnose, treat, cure or prevent any disease. Always follow the advice of your prescribing practitioner.

When used as directed and as part of a comprehensive lifestyle and medical plan, clients commonly use Sermorelin to help support:

Deeper, more restorative sleep

Sermorelin works with the body’s natural growth hormone rhythm, which peaks at night, and many people report more settled, restorative sleep and better “next day” recovery.

Lean muscle maintenance and strength

By gently supporting growth hormone and IGF-1, Sermorelin can help protect lean muscle and support strength gains when combined with resistance training and adequate protein intake.

Body recomposition and fat-loss efforts

Sermorelin is often used in fat-loss or recomposition programs to help shift more of the weight change towards fat rather than muscle, especially when diet and movement are dialled in.

Recovery from training and busy schedules

Supporting natural repair pathways may help the body bounce back more effectively from exercise, physical work and the general demands of a high-output lifestyle.

Daytime energy, mood and resilience

Better sleep, improved recovery and more stable hormone signalling can translate into more consistent energy, better mood and a greater capacity to handle daily stress.

Healthy-ageing and long-term tissue support

Sermorelin is frequently included in healthy-ageing programs to support bone, muscle, connective tissue and overall vitality by nudging the growth hormone axis rather than overriding it.

*Individual results will vary. Best used as part of a complete plan designed by your healthcare provider.

Presentation

5mL multidose vial 

(Total peptide content: Sermorelin 200mcg/mL)

Excipients

Sterile diluent (e.g., bacteriostatic saline) and standard compounding excipients as specified by the partner pharmacy (may include buffering agents and preservatives).

Protocol & Standard Dosing

Subcutaneous injection into fatty tissue (e.g., lower abdomen, outer thigh), using an insulin type syringe, as instructed by a healthcare professional.

Standard Dose (Maintenance / Symptom Support)

Injectable (Vial)

< 70 kg: 0.10 mL SC nightly on an empty stomach, 5 days per week (5/7)

> 70 kg: 0.15 mL SC nightly on an empty stomach, 5 days per week (5/7)

Administration Method:

Subcutaneous (SC) injection using an insulin syringe into fatty tissue (e.g., lower abdomen or outer thigh), as instructed by a healthcare professional.

Timing & Frequency:

Inject last thing before bed, at least 2 hours after the last meal, and/or upon waking.

Avoid food for 30 minutes after injection.

Use 5 days on / 2 days off each week (5/7 days).

Increased dosing:

May increase to 0.10 mL twice daily in smaller individuals

Or 0.15 mL twice daily in larger individuals

Only if tolerated and clinically indicated, under prescriber guidance.

Side Effects, Reactions & Medical Contraindications

Use is generally not recommended in:

• Known allergy or hypersensitivity to Sermorelin or any vial component
• Pregnancy or breastfeeding (insufficient safety data)
• Active malignancy or a history of cancer unless cleared and monitored by an appropriate specialist (due to GH/IGF-1–related growth pathways)
• Uncontrolled diabetes, significant cardiovascular disease, severe kidney or liver disease without specialist supervision
• Known pituitary tumours or unexplained pituitary dysfunction unless managed by an endocrinologist
• Clients should always provide a full medical history and medication list before starting Sermorelin.

Common Side Effects and Adverse Reactions

• Most reported side effects are mild and often settle as the body adjusts. They can include:
• Injection-site reactions – redness, itching, small bruises or mild swelling
• Water retention or puffiness, especially at higher doses
• Headache, light-headedness or fatigue, particularly in the first weeks
• Increased appetite, vivid dreams or changes in sleep pattern
• If these symptoms are persistent, uncomfortable or worrying, your clinician may adjust the dose, change timing or pause treatment. 

Reactions Requiring Medical Attention

• Stop injections and seek medical care (or emergency services if severe) if you notice:
• Signs of a serious allergic reaction – widespread rash or hives, swelling of face/lips/tongue, difficulty breathing or swallowing
• Severe or persistent headache, visual changes, chest pain or marked shortness of breath
• Significant ankle/hand swelling, rapid unexplained weight gain, or major changes in blood pressure
• Any new or worsening symptom that feels serious, unusual or concerning

Safety Note

Sermorelin is a prescription-only peptide therapy and long-term data in wellness/optimisation populations are still evolving. It should:

• Only be used under qualified medical supervision
• Include regular monitoring of IGF-1, metabolic markers and clinical response
• Be understood as one supportive tool, not a substitute for healthy nutrition, movement, sleep or appropriate medical treatment
• Informed consent is essential so clients understand potential benefits, risks, uncertainties and alternative options.

Safety Note: Long‑term data is limited. Use should always be monitored by a qualified clinician, with regular reviews and ongoing medical supervision.  Informed consent is essential.