Epitalon (also known as epithalon or epithalamin-derived peptide) is a synthetic tetrapeptide originally developed from a naturally occurring pineal-gland extract. It’s most widely known in longevity and regenerative medicine circles for its potential role in supporting cellular ageing pathways, melatonin regulation and sleep–wake rhythm.

Epitalon works on complex signalling systems. It’s been explored for its potential to support more youthful melatonin rhythms, which are closely linked with sleep quality and night-time recovery. Epitalon can also potentially influence cellular repair and turnover, including telomere-related pathways in some experimental work, but more importantly help the body re-establish more balanced day–night (circadian) rhythms

Clients typically use Epitalon as part of a healthy-ageing or optimisation protocol when they want to support sleep quality, recovery, immune balance and long-term vitality.

EPITALON is not an FDA‑approved medicine and is not intended to diagnose, treat, cure or prevent any disease. Always follow the advice of your prescribing practitioner.

When used as directed and as part of a complete health plan, clients commonly use Epitalon to help support:

Healthy sleep–wake rhythm

By acting at the level of the pineal gland and melatonin pathways, Epitalon is often used to support more regular sleep timing and improved night-time recovery.

Deep rest & next-day recovery

Many clients use Epitalon during periods of high stress, heavy training or demanding schedules to support deeper rest and feeling more restored on waking.

Healthy-ageing and cellular support

Epitalon is frequently included in longevity programs to support cellular repair and healthy ageing pathways, alongside nutrition, exercise and other lifestyle interventions.

Immune and overall resilience

Because sleep, circadian rhythm and cellular repair are closely tied to immune function, Epitalon is used as one pillar in broader protocols aimed at supporting long-term resilience.

*Individual results will vary. Best used as part of a complete plan designed by your healthcare provider.

Active Ingredient

Epitalon peptide

Presentation

Injectable

Epitalon 5,000 mcg/mL – 5 mL multidose vial

Capsules

3 mg Epitalon per capsule

30 capsules per bottle

Protocol & Standard Dosing

Epitalon – Injectable (5 mL vial, 5,000 mcg/mL)

0.50 mL – 1ml (50 – 100 units on a standard 1 mL insulin syringe)

Route: Subcutaneous injection

Timing

Once per day

Frequency / Cycle

One dose every day for a 10-day cycle. 1 or two cycles yearly.

Dosing & Administration Instructions (Injectable)

Inject 0.50 mL via subcutaneous injection, once daily, for 10 consecutive days.

Inject into fatty tissue (e.g. lower abdomen, outer thigh) as shown by your healthcare professional.

Use aseptic technique and rotate injection sites to minimise local irritation.

Epitalon Micro – Oral Capsules (3 mg, 30 capsules)

1 capsule

Application

Take with food and swallow with water.

Timing

Morning

Frequency / Cycle

One dose per day, Monday to Friday, every second week.

Dosing & Administration Instructions (Capsules)

Take one capsule each morning with water and food.

Take one daily dose from Monday to Friday every second week (e.g. week on, week off).

Side Effects, Reactions & Medical Contraindications

Use is generally not recommended in:

• Known allergy or hypersensitivity to Epitalon or any component of the vial/capsule
• Pregnancy or breastfeeding (insufficient safety data)
• Active malignancy or history of cancer unless cleared by an appropriate specialist (due to theoretical links with cell-cycle regulation)
• Uncontrolled significant chronic illness (e.g. severe cardiovascular, renal, hepatic or neurological disease) without specialist supervision
• Individuals on complex hormone, sleep or psychiatric medications without medical oversight, due to potential interactions with sleep and neuroendocrine pathways

Common Side Effects and Adverse Reactions – Often mild and transient where they occur:

Injectable

• Injection-site redness, itching, mild swelling or small bruises
• Temporary warmth or tingling at injection site
• Mild headache, light-headedness or transient fatigue during the first few days

Capsules

• Mild digestive upset: nausea, stomach discomfort or loose stools
• Headache or a “heavy” feeling if dosing is too late in the day
• Changes in sleep pattern initially (e.g. more vivid dreams or feeling sleepier than usual as rhythm adjusts)
• If side effects are persistent, uncomfortable or worrying, contact your healthcare provider to review dose, timing or whether to pause.

Reactions Requiring Medical Attention

• Stop treatment and contact a healthcare provider (or emergency services if severe) if experiencing:
• Signs of a serious allergic reaction: widespread rash, hives, facial or tongue swelling, difficulty breathing
• Severe or persistent headache, visual changes, chest pain or shortness of breath
• Marked changes in mood, behaviour or cognition (e.g. confusion, agitation, very low mood)
• Any new or worsening symptom that feels serious, unusual or concerning

Safety Note: Long‑term data is limited. Use should always be monitored by a qualified clinician, with regular reviews and ongoing medical supervision.  Informed consent is essential.