GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper-binding peptide found in the body, particularly in plasma and tissues. It’s known for its role in skin repair, collagen support and healthy tissue remodelling, and is often used in cosmetic and regenerative protocols aimed at improving skin quality and visible signs of aging.

We have two options for this peptide.

In injectable form, GHK-Cu is used in advanced protocols to support broader tissue repair, recovery and healthy aging from the inside out.

In topical cream form, it is applied directly to the skin for more targeted cosmetic benefits.

GHK-Cu is not an FDA-approved medication and is not intended to diagnose, treat, cure or prevent any disease. Your healthcare practitioner will advise whether DSIP is suitable for your situation.

When used as directed and alongside a healthy lifestyle, clients commonly use GHK-Cu to help support:

Smoother, firmer-looking skin

GHK-Cu is widely used to support collagen and elastin, helping improve the look of fine lines, texture and overall firmness when used consistently.

Improved skin tone & radiance

Many people notice their skin looks brighter and more even, with a “refreshed” appearance as cell turnover and barrier support improve.

Support for stressed or mature skin

Ideal for skin exposed to the sun, pollution or daily stressors, as well as skin showing early or established signs of ageing.

Post-procedural or recovery support (topical use)

Under practitioner guidance, GHK-Cu creams are often incorporated into post-procedure skincare routines (e.g. following cosmetic treatments) to support the skin’s natural repair processes.

Tissue repair & healthy ageing (injectable use)

In injectable protocols, GHK-Cu is used as part of more advanced regenerative or healthy-ageing programs aimed at supporting overall tissue integrity and recovery.plan that includes sleep hygiene, nervous-system regulation, nutrition and movement.

*Individual results vary. GHK-Cu works best as part of a complete plan created with your healthcare provider and is not a replacement for good skincare, sun protection, nutrition or medical care.

Active Ingredient

GHK-Cu (Copper Peptide)

Presentation

Injectable

GHK-Cu 100 mcg/mL, 5 mL multidose vial

Topical Creams

GHK-Cu 0.50% cream, 30 mL

GHK-Cu 4% cream, 10 mL

Protocol & Standard Dosing

Subcutaneous injection into fatty tissue (e.g., lower abdomen, outer thigh), using an insulin type syringe, as instructed by a healthcare professional.

Standard Dose

Injectable – 100 mcg/mL, 5 mL vial

Typical starting dose: 0.10 mL subcutaneous (SC) injection, once daily or 3–5 times per week, as directed by the prescriber.

Inject into fatty tissue (e.g. lower abdomen, outer thigh) using an insulin syringe, as taught by a healthcare professional.

Timing

Often used in the evening or post-training, depending on the overall program.

Can be taken with or without food, following prescriber advice.

Course Length

Commonly used over 6–12 weeks, with review and adjustment depending on goals, response and tolerance.

Dose Adjustments

Dose or frequency may be increased or decreased only under practitioner guidance (e.g. up to 0.20 mL per dose in selected cases).

Self-adjustment of dose is not recommended.

Topical Cream – 0.50% (30 mL)

Apply a pea-sized amount to clean, dry skin of the face, neck and/or décolletage, once nightly.

Gently massage until absorbed. Can be followed with a simple moisturiser if required.

Timing

Best used at night after cleansing and before heavier creams or oils.

Always use broad-spectrum sunscreen during the day when using active skincare.

Topical Cream – 4% (10 mL) – High-Strength/Targeted Use

Designed for targeted areas or advanced protocols as advised by your practitioner.

Apply a very small amount (rice-grain sized) to the specific area(s) of concern, typically once nightly.

Introductory Schedule

Many clients are advised to start every second night, then build to nightly use if tolerated.

Can be layered under or mixed with a bland moisturiser in sensitive skin to reduce intensity.

Course Length – Both Creams

Typically used for 8–12 weeks or longer as part of an ongoing skincare plan, with periodic review by your practitioner.

Side Effects, Reactions & Medical Contraindications

Use is generally not recommended in:

• Known allergy or hypersensitivity to GHK-Cu, copper, or any component of the vial/cream base
• Pregnancy or breastfeeding (insufficient safety data for injectable or high-strength topical use)
• Active malignancy or history of cancer unless cleared by a specialist (due to theoretical effects on cell signalling and tissue remodelling)
• Significant liver or kidney disease without specialist supervision (as these organs are involved in copper handling and clearance)
• Known disorders of copper metabolism (e.g. Wilson’s disease) or unexplained abnormal copper levels
• Broken, infected or extensively inflamed skin at the intended cream application site

Common Side Effects and Adverse Reactions – Often mild and transient where they occur:

Injectable (100 mcg/mL, 5 mL vial)

• Injection-site redness, itching, mild swelling or small bruises
• Temporary warmth or tingling around the injection area
• Mild headache, light-headedness or transient fatigue

Topical Cream (0.50% 30 mL and 4% 10 mL)

• Local skin irritation: redness, dryness, itching or mild burning after application
• Temporary skin tightness or mild flaking as skin turnover changes
• Occasionally, mild blue-green discolouration at the application site due to copper content
• If irritation is persistent or uncomfortable, your practitioner may recommend reducing frequency, applying a smaller amount, buffering with a moisturiser, or pausing use.

Reactions Requiring Medical Attention – Stop using GHK-Cu and contact a healthcare provider (or emergency services if severe) if experiencing:

• Signs of a serious allergic reaction: widespread rash, hives, facial or tongue swelling, difficulty breathing
• Severe, blistering or ulcerating skin reactions at the injection or application site
• Severe or persistent headache, chest pain, shortness of breath or marked dizziness
• Signs suggestive of copper overload or systemic reaction (e.g. unexplained nausea/vomiting, abdominal pain, yellowing of the skin or eyes, dark urine)
• Any new or worsening symptom that feels serious, unusual or concerning

Safety Note: Long‑term data is limited. Use should always be monitored by a qualified clinician, with regular reviews and ongoing medical supervision.  Informed consent is essential.